Fenestrated Glomerular Capillaries Are Unique
نویسندگان
چکیده
منابع مشابه
The Permeability of Glomerular Capillaries to Graded Dextrans
Graded dextrans have been used as tracers to identify the primary permeability barrier(s) to macromolecules among the structural elements (endothelium, mesangium, basement membrane, epithelium) of the glomerular capillary wall. Three narrow-range fractions of specified molecular weights and Einstein-Stokes radii (ESR) were prepared by gel filtration: (a) 32,000 mol wt, ESR = 38 A; (b) 62,000 mo...
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Nicholas Ferrell, Ruben M. Sandoval, Aihua Bian, Silvia B. Campos-Bilderback, Bruce A. Molitoris, and William H. Fissell Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee; Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee; and Roudebush Veterans Affairs M...
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Loss of significant functional renal mass results in compensatory structural and hemodynamic adaptations in the nephron. While these changes have been characterized in several injury models, how they affect hemodynamic forces at the glomerular capillary wall has not been adequately characterized, despite their potential physiological significance. Therefore, we used intravital multiphoton micro...
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Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function. However, VEGF is a survival factor for many tumor vessels, and there are clues that some normal blood vessels may also depend on VEGF. In this study, we sought to identify which, if any, vascular beds in adult mice depend on VEGF for survival. Mice were treated with a small-molec...
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Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained d...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2008060583